窄叶鲜卑花地上部分化学成分研究

姚争争, 刘德鸿, 陈笑天, 李斐, 周翔, 潘玲玲, 吴亚芬, 张东明, 李斌

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (4) : 263-267.

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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (4) : 263-267. DOI: 10.11669/cpj.2018.04.004
论著

窄叶鲜卑花地上部分化学成分研究

  • 姚争争1, 刘德鸿1, 陈笑天1, 李斐1, 周翔1, 潘玲玲1, 吴亚芬1, 张东明2, 李斌1*
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Chemical Constituents from the Aerial Part of Sibiraea angustata

  • YAO Zheng-zheng1, LIU De-hong1, CHEN Xiao-tian1, LI Fei1, ZHOU Xiang1, PAN Ling-ling1, WU Ya-fen1, ZHANG Dong-ming2, LI Bin1*
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摘要

目的 研究窄叶鲜卑花地上部分水提物的化学成分。方法 采用HP-20大孔吸附树脂、凝胶柱色谱、反相柱色谱和制备液相色谱等方法进行分离纯化;通过理化性质、波谱数据并结合文献报道数据对比确定化合物结构。结果 从窄叶鲜卑花地上部分水提物中共分离得到12个化合物,分别鉴定为:藜芦酸(1)、(+)-cycloolivil(2)、3,7-dimethyl-3(E),6-octadien-5-one-1-O-β-D-glucoside(3)、3,7-dimethyl-3(Z)-6-octadien-5-one-1-O-β-D-glucoside(4)、1-O-β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl-3,7-dimethyl-2(E)-6-heptdiene(5)、(7R,8S)-二氢脱氢二松柏醇-9′-O-β-D-吡喃葡萄糖苷(6)、(+)-1-hydroxypinoresinol-1-β-D-glucoside(7)、茵芋苷(8)、kaempferol 3-O-α-L-arabinopyranosyl-(1→6)-β-D-galactopyranoside(9)、异鼠李素-3-O-[β-D-半乳糖(1→6)]-β-D-葡萄糖苷(10)、isorhamnetin 3-O-α-arabinopyranosyl-(1→6)-β-galactopyranoside(11)和quercetin 3-O-[2'''-O-(E)-caffeoyl]-α-L-arabinopyranosyl-(1→6)-β-D-galactopyranoside(12)。结论 所有化合物均为首次从鲜卑花属植物中分离得到。

Abstract

OBJECTIVE To study the chemical constituents of the aqueous extract from the aerial part of Sibiraea angustata. METHODS The constituents were isolated by various chromatographic techniques(HP-20 macroporous absorption resin, Sephadex LH-20 gel, Reverse-phase silical gel and PHPLC) and their structures were determined on the basis of physicochemical properties and their spectroscopic data, as well as the literatures. RESULTS Twelve compounds were separated and identified as veratric acid(1),(+)-cycloolivil(2), 3,7-dimethyl-3(E)-6-octadien-5-one-1-O-β-D-glucoside(3), 3,7-dimethyl-3(Z)-6-octadien-5-one-1-O-β-D-glucoside(4), 1-O-β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl-3,7-dimethyl-2(E)-6-heptdiene(5),(7R,8S)-dihydrodehydrodiconiferyl alcohol-9′-O-β-D-glucopyranoside(6),(+)-1-hydroxypinoresinol-1-β-D-glucoside(7), skimmin(8), kaempferol 3-O-α-L-arabinopyranosyl-(1→6)-β-D-galactopyranoside(9), isorhamnetin-3-O-β-D-galactopyranosyl(1→6)-β-D-glucopyranoside(10), isorhamnetin 3-O-α-arabinopyranosyl-(1→6)-β-galactopyranoside(11), and quercetin 3-O-[2'''-O-(E)-caffeoyl]-α-L-arabinopyranosyl-(1→6)-β-D-galactopyranoside(12). CONCLUSION All compounds are obtained from the genus of Sibiraea for the first time.

关键词

窄叶鲜卑花 / 地上部分 / 藜芦酸 / (7R / 8S)-二氢脱氢二松柏醇9′-O-β-D-吡喃葡萄糖苷 / 茵芋苷 / 异鼠李素-3-O-[β-D-半乳糖(1→6)]-β-D-葡萄糖苷

Key words

Sibiraea angustata / aerial part / veratric acid / (7R,8S)-dihydrodehydrodiconiferyl alcohol-9′-O-β-D-glucopyranoside / skimming / isorhamnetin-3-O-β-D-galactopyranosyl(1→6)-β-D-glucopyranoside

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姚争争, 刘德鸿, 陈笑天, 李斐, 周翔, 潘玲玲, 吴亚芬, 张东明, 李斌. 窄叶鲜卑花地上部分化学成分研究[J]. 中国药学杂志, 2018, 53(4): 263-267 https://doi.org/10.11669/cpj.2018.04.004
YAO Zheng-zheng, LIU De-hong, CHEN Xiao-tian, LI Fei, ZHOU Xiang, PAN Ling-ling, WU Ya-fen, ZHANG Dong-ming, LI Bin. Chemical Constituents from the Aerial Part of Sibiraea angustata[J]. Chinese Pharmaceutical Journal, 2018, 53(4): 263-267 https://doi.org/10.11669/cpj.2018.04.004
中图分类号: R284   

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基金

国家自然科学基金资助项目(81760708);江西省主要学科学术和技术带头人资助计划项目资助(20162BCB22016);江西省教育厅重点项目资助(GJJ160809)
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